Comment on: Høeg et al. Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling. Diabetes 2011;60:64–73

I read with interest the article by Hoeg et al. (1) in the January issue of Diabetes in which the authors concluded that there is a sex difference in the response in free fatty acid (FFA)-induced skeletal muscle insulin resistance following a lipid infusion in nonobese healthy humans. This was based on a rather small difference of marginal statistical significance ( P < 0.05), and it was only the case for the glucose infusion over 120 min (Fig. 1 B ), but not over the last 30 min (which would be of greater value because it is closer to steady state; Fig. 1 A ) or when expressed by overall kilogram of body mass (31 ± 3 vs. 29 ± …