Response to Comment on: Ott et al. Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes 2011;60:572–576 | Zendy

Christian Ott | Zendy; Markus P. Schneider | Zendy; Roland E. Schmieder | Zendy

Open Access

Response to Comment on: Ott et al. Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes 2011;60:572–576

Author(s) -

Christian Ott,

Markus P. Schneider,

Roland E. Schmieder

Publication year - 2011

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db11-0602

Subject(s) - nitric oxide , albuminuria , nitric oxide synthase , endocrinology , basal (medicine) , medicine , diabetes mellitus , omega n methylarginine , arginine , chemistry , biochemistry , amino acid

We thank Tsikas et al. (1) for their interest in our recent work. Tsikas et al. comment that we did not provide direct evidence of reduced nitric oxide (NO) synthesis. No direct approach is available in humans. However, N G-monomethyl-l-arginine (L-NMMA) is a specific NO synthase (NOS) inhibitor, i.e., the changes we reported are due to NOS inhibition. In the cited publication by Tsikas et al., long-term (chronic) effects and indirect markers of (systemic) NO metabolism (plasma nitrites and …

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