Comment on: Kim et al. (2010) Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight. Diabetes;59:2772–2780 | Zendy

Michael Wilkinson | Zendy; Russell E. Brown | Zendy; Syed Ali Imran | Zendy; Ehud Ur | Zendy

Open Access

Comment on: Kim et al. (2010) Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight. Diabetes;59:2772–2780

Author(s) -

Michael Wilkinson,

Russell E. Brown,

Syed Ali Imran,

Ehud Ur

Publication year - 2010

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db10-1348

Subject(s) - regulator , adipokine , food intake , angptl4 , hypothalamus , body weight , biology , medicine , endocrinology , diabetes mellitus , leptin , obesity , gene , genetics

The article by Kim et al. (1) outlines a detailed series of experiments that purport to establish angiopoietin-like protein 4(Angptl4)/fasting- induced adipose factor (Fiaf) as a novel hypothalamic regulator of food intake and body weight in the mouse. Although the results of this study are impressive, we note that all previous publications on the regulation of fiaf in the murine brain were overlooked. For example, in our ongoing studies of adipokine gene expression in the nervous …

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