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We appreciate the response by Rother and Harlan (1) to our article (2). However, it is difficult to understand what the confirmatory aspects of the Medalist Study data are with respect to the studies of Liu et al. (3) and Rother et al. (4), which documented minimal levels of C-peptide production in individuals with a diabetes duration of 19.2 ± 11.8 years and 21.3 ± 10.7 years, respectively. Clearly, this duration …

diabetes

Response to Comment on: Keenan et al. (2010) Residual Insulin Production and Pancreatic β-Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study. Diabetes 2010;59:2846–2853