Response to Comment on: Biscetti et al. (2010) High-Mobility Group Box-1 Protein Promotes Angiogenesis After Peripheral Ischemia in Diabetic Mice Through a VEGF-Dependent Mechanism. Diabetes;59:1496–1505

We thank Germani and Capogrossi (1) for showing interest in our work (5). Previous studies, especially reports by Germani and colleagues (2–4), document that high-mobility group box-1 (HMGB1) could be involved in the molecular mechanisms that regulate angiogenesis. As reported in our article (5), we started from the previous findings that showed that endogenous HMGB1 …