Comment on: Biscetti et al. (2010) High-Mobility Group Box-1 Protein Promotes Angiogenesis After Peripheral Ischemia in Diabetic Mice Through a VEGF-Dependent Mechanism. Diabetes;59:1496–1505 | Zendy

Antonia Germani | Zendy; Maurizio C. Capogrossi | Zendy

Open Access

Comment on: Biscetti et al. (2010) High-Mobility Group Box-1 Protein Promotes Angiogenesis After Peripheral Ischemia in Diabetic Mice Through a VEGF-Dependent Mechanism. Diabetes;59:1496–1505

Author(s) -

Antonia Germani,

Maurizio C. Capogrossi

Publication year - 2010

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db10-0445

Subject(s) - hmgb1 , angiogenesis , diabetes mellitus , high mobility group , ischemia , medicine , skeletal muscle , mechanism (biology) , vegf receptors , peripheral , endocrinology , biology , inflammation , biochemistry , philosophy , epistemology , gene

In a recent Diabetes article, Biscetti et al. (1) report that high-mobility group box-1 (HMGB1) protein levels are reduced in the skeletal muscle of diabetic mice and that exogenous HMGB1 administration, following the induction of hindlimb ischemia, promotes angiogenesis through a VEGF-dependent mechanism.With regard to the angiogenic effect of HMGB1, we have previously demonstrated that both HMGB1 administration and …

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