Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats | Zendy

Alexandre G. Oliveira | Zendy; Bruno M. Carvalho | Zendy; Natália Tobar | Zendy; Eduardo R. Ropelle | Zendy; José Rodrigo Pauli | Zendy; Renata A. Bagarolli | Zendy; Dioze Guadagnini | Zendy; José Barreto Campello Carvalheira | Zendy; Mário J.A. Saad | Zendy

Open Access

Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats

Author(s) -

Alexandre G. Oliveira,

Bruno M. Carvalho,

Natália Tobar,

Eduardo R. Ropelle,

José Rodrigo Pauli,

Renata A. Bagarolli,

Dioze Guadagnini,

José Barreto Campello Carvalheira,

Mário J.A. Saad

Publication year - 2011

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db09-1907

Subject(s) - insulin resistance , insulin receptor , medicine , endocrinology , tlr4 , adipose tissue , inflammation , phosphorylation , insulin , protein kinase b , signal transduction , kinase , biology , biochemistry

Insulin resistance in diet-induced obesity (DIO) is associated with a chronic systemic low-grade inflammation, and Toll-like receptor 4 (TLR4) plays an important role in the link among insulin resistance, inflammation, and obesity. The current study aimed to analyze the effect of exercise on TLR4 expression and activation in obese rats and its consequences on insulin sensitivity and signaling.

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