The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes | Zendy

Pontus Boström | Zendy; Linda Andersson | Zendy; Birgitte F. Vind | Zendy; Liliana Håversen | Zendy; Mikael Rutberg | Zendy; Ylva Wickström | Zendy; Erik Larsson | Zendy; PerAnders Jansson | Zendy; Maria Svensson | Zendy; Rickard Brånemark | Zendy; Charlotte Ling | Zendy; Henning BeckNielsen | Zendy; Jan Borén | Zendy; Kurt Højlund | Zendy; SvenOlof Olofsson | Zendy

Open Access

The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes

Author(s) -

Pontus Boström,

Linda Andersson,

Birgitte F. Vind,

Liliana Håversen,

Mikael Rutberg,

Ylva Wickström,

Erik Larsson,

PerAnders Jansson,

Maria Svensson,

Rickard Brånemark,

Charlotte Ling,

Henning BeckNielsen,

Jan Borén,

Kurt Højlund,

SvenOlof Olofsson

Publication year - 2010

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db09-1503

Subject(s) - snap23 , skeletal muscle , insulin resistance , endocrinology , medicine , biology , type 2 diabetes , diabetes mellitus , microbiology and biotechnology , membrane protein , biochemistry , vesicle associated membrane protein 8 , membrane

Our previous studies suggest that the SNARE protein synaptosomal-associated protein of 23 kDa (SNAP23) is involved in the link between increased lipid levels and insulin resistance in cardiomyocytes. The objective was to determine whether SNAP23 may also be involved in the known association between lipid accumulation in skeletal muscle and insulin resistance/type 2 diabetes in humans, as well as to identify a potential regulator of SNAP23.

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