Reduced Glucocorticoid Production Rate, Decreased 5α-Reductase Activity, and Adipose Tissue Insulin Sensitization After Weight Loss | Zendy

Jeremy Tomlinson | Zendy; Joanne Finney | Zendy; Beverly Hughes | Zendy; Susan V. Hughes | Zendy; Paul M. Stewart | Zendy

Open Access

Reduced Glucocorticoid Production Rate, Decreased 5α-Reductase Activity, and Adipose Tissue Insulin Sensitization After Weight Loss

Author(s) -

Jeremy Tomlinson,

Joanne Finney,

Beverly Hughes,

Susan V. Hughes,

Paul M. Stewart

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db08-0094

Subject(s) - medicine , endocrinology , adipose tissue , glucocorticoid , insulin resistance , lipolysis , insulin , 11β hydroxysteroid dehydrogenase type 1 , weight loss , hyperinsulinemia , chemistry , biology , obesity , dehydrogenase , enzyme , biochemistry

The epidemics of obesity, insulin resistance, and type 2 diabetes have heightened the need to understand mechanisms that contribute to their pathogenesis. Increased endogenous glucocorticoid production has been implicated based on parallels with Cushing's syndrome. We have assessed the impact of weight loss on glucocorticoid secretion and metabolism (notably 11beta-hydroxysteroid dehydrogenase type 1 and 5alpha-reductase [5alphaR] activity) and insulin sensitivity.

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