Decreased Lipoprotein Clearance Is Responsible for Increased Cholesterol in LDL Receptor Knockout Mice With Streptozotocin-Induced Diabetes | Zendy

Ira J. Goldberg | Zendy; Yunying Hu | Zendy; Hye Lim Noh | Zendy; Justin Wei | Zendy; Lesley A. Huggins | Zendy; Marnie G. Rackmill | Zendy; Hiroko Hamai | Zendy; Brendan N. Reid | Zendy; William S. Blaner | Zendy; LiShin Huang | Zendy

Open Access

Decreased Lipoprotein Clearance Is Responsible for Increased Cholesterol in LDL Receptor Knockout Mice With Streptozotocin-Induced Diabetes

Author(s) -

Ira J. Goldberg,

Yunying Hu,

Hye Lim Noh,

Justin Wei,

Lesley A. Huggins,

Marnie G. Rackmill,

Hiroko Hamai,

Brendan N. Reid,

William S. Blaner,

LiShin Huang

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db08-0083

Subject(s) - medicine , endocrinology , ldl receptor , streptozotocin , diabetes mellitus , cholesterol , dyslipidemia , apolipoprotein b , chemistry , postprandial , very low density lipoprotein , apolipoprotein e , hyperlipidemia , lipoprotein , disease

Patients with diabetes often have dyslipidemia and increased postprandial lipidmia. Induction of diabetes in LDL receptor (Ldlr(-/-)) knockout mice also leads to marked dyslipidemia. The reasons for this are unclear.

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