Abnormal Muscle Spindle Innervation and Large-Fiber Neuropathy in Diabetic Mice | Zendy

Karra A. Muller | Zendy; Janelle M. Ryals | Zendy; Eva L. Feldman | Zendy; Douglas E. Wright | Zendy

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Abnormal Muscle Spindle Innervation and Large-Fiber Neuropathy in Diabetic Mice

Author(s) -

Karra A. Muller,

Janelle M. Ryals,

Eva L. Feldman,

Douglas E. Wright

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db08-0022

Subject(s) - axon , diabetes mellitus , streptozotocin , medicine , balance (ability) , endocrinology , nerve fiber , gait , anatomy , physical medicine and rehabilitation

Large-fiber diabetic polyneuropathy (DPN) leads to balance and gait abnormalities, placing patients at risk for falls. Large sensory axons innervating muscle spindles provide feedback for balance and gait and, when damaged, can cause altered sensorimotor function. This study aimed to determine whether symptoms of large-fiber DPN in type 1 and type 2 diabetic mouse models are related to alterations in muscle spindle innervation. In addition, diabetic mice were treated with insulin to assess whether sensorimotor and spindle deficits were reversible.

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