The Frequency and Immunodominance of Islet-Specific CD8+ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment | Zendy

Emanuela Martinuzzi | Zendy; Giulia Novelli | Zendy; Matthieu Scotto | Zendy; Philippe Blancou | Zendy; JeanMarie Bach | Zendy; Lucy Chaillous | Zendy; Graziella Bruno | Zendy; Lucienne Chatenoud | Zendy; Peter Van Endert | Zendy; Roberto Mallone | Zendy

Open Access

The Frequency and Immunodominance of Islet-Specific CD8+ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment

Author(s) -

Emanuela Martinuzzi,

Giulia Novelli,

Matthieu Scotto,

Philippe Blancou,

JeanMarie Bach,

Lucy Chaillous,

Graziella Bruno,

Lucienne Chatenoud,

Peter Van Endert,

Roberto Mallone

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-1594

Subject(s) - immunodominance , epitope , islet , insulitis , immunology , cd8 , t cell , autoantibody , subdominant , biology , elispot , beta cell , antigen , endocrinology , medicine , diabetes mellitus , immune system , antibody

Islet-reactive CD8(+) T-cells play a key role in the pathogenesis of type 1 diabetes in the NOD mouse. The predominant T-cell specificities change over time, but whether similar shifts also occur after clinical diagnosis and insulin treatment in type 1 diabetic patients is unknown.

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