Critical Roles for Macrophages in Islet Angiogenesis and Maintenance During Pancreatic Degeneration | Zendy

Jeffery S. Tessem | Zendy; Jan Jensen | Zendy; Hanna Seppänen | Zendy; Xuming Dai | Zendy; Xiaohua Zong | Zendy; E. Richard Stanley | Zendy; James DeGregori | Zendy

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Critical Roles for Macrophages in Islet Angiogenesis and Maintenance During Pancreatic Degeneration

Author(s) -

Jeffery S. Tessem,

Jan Jensen,

Hanna Seppänen,

Xuming Dai,

Xiaohua Zong,

E. Richard Stanley,

James DeGregori

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-1577

Subject(s) - islet , angiogenesis , pancreatitis , endocrinology , medicine , pancreas , pancreatic islets , biology , bone marrow , cancer research , transplantation , diabetes mellitus

Chronic pancreatitis, characterized by pancreatic exocrine tissue destruction with initial maintenance of islets, eventually leads to insulin-dependent diabetes in most patients. Mice deficient for the transcription factors E2F1 and E2F2 suffer from a chronic pancreatitis-like syndrome and become diabetic. Surprisingly, onset of diabetes can be prevented through bone marrow transplantation. The goal of the described studies was to determine the hematopoietic cell type responsible for maintaining islets and the associated mechanism of this protection.

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