Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic β-Cells | Zendy

Karim Bouzakri | Zendy; Pascale Ribaux | Zendy; Alejandra Tomás | Zendy; Géraldine Parnaud | Zendy; Katharina Rickenbach | Zendy; Philippe A. Halban | Zendy

Open Access

Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic β-Cells

Author(s) -

Karim Bouzakri,

Pascale Ribaux,

Alejandra Tomás,

Géraldine Parnaud,

Katharina Rickenbach,

Philippe A. Halban

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-1469

Subject(s) - protein kinase b , glut4 , biology , microbiology and biotechnology , insulin receptor , pancreatic islets , small interfering rna , medicine , glucose transporter , endocrinology , insulin , chemistry , signal transduction , transfection , islet , cell culture , insulin resistance , genetics

Protein kinase B/Akt plays a central role in beta-cells, but little is known regarding downstream Akt substrates in these cells. Recently, Rab GTPase-activating protein AS160, a substrate of Akt, was shown to be involved in insulin modulation of GLUT4 trafficking in skeletal muscle and adipose tissue. The aim of this study was to investigate the expression and potential role of AS160 in beta-cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research