Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI | Zendy

Rachel M. Freathy | Zendy; Nicholas J. Timpson | Zendy; Debbie A. Lawlor | Zendy; Anneli Pouta | Zendy; Yoav BenShlomo | Zendy; Aimo Ruokonen | Zendy; Shah Ebrahim | Zendy; Beverley M. Shields | Zendy; Eleftheria Zeggini | Zendy; Michael N. Weedon | Zendy; Cecilia M. Lindgren | Zendy; Hana Lango Allen | Zendy; David Melzer | Zendy; Luigi Ferrucci | Zendy; Giuseppe Paolisso | Zendy; Matthew Neville | Zendy; Fredrik Karpe | Zendy; Nicholette D. Palmer | Zendy; Andrew D. Morris | Zendy; Paul Elliott | Zendy; MarjoRiitta Järvelin | Zendy; George Davey Smith | Zendy; Mark I. McCarthy | Zendy; Andrew T. Hattersley | Zendy; Timothy M. Frayling | Zendy

Open Access

Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI

Author(s) -

Rachel M. Freathy,

Nicholas J. Timpson,

Debbie A. Lawlor,

Anneli Pouta,

Yoav BenShlomo,

Aimo Ruokonen,

Shah Ebrahim,

Beverley M. Shields,

Eleftheria Zeggini,

Michael N. Weedon,

Cecilia M. Lindgren,

Hana Lango Allen,

David Melzer,

Luigi Ferrucci,

Giuseppe Paolisso,

Matthew Neville,

Fredrik Karpe,

Nicholette D. Palmer,

Andrew D. Morris,

Paul Elliott,

MarjoRiitta Järvelin,

George Davey Smith,

Mark I. McCarthy,

Andrew T. Hattersley,

Timothy M. Frayling

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-1466

Subject(s) - medicine , endocrinology , fto gene , obesity , type 2 diabetes , odds ratio , metabolic syndrome , genotype , diabetes mellitus , body mass index , insulin resistance , biology , polymorphism (computer science) , genetics , gene

Common variation in the FTO gene is associated with BMI and type 2 diabetes. Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in these metabolic traits.

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