Reversal of Streptozotocin-Induced Diabetes in Mice by Cellular Transduction With Recombinant Pancreatic Transcription Factor Pancreatic Duodenal Homeobox-1 | Zendy

Vijay Koya | Zendy; Shun Lu | Zendy; Yuping Sun | Zendy; Daniel L. Purich | Zendy; Mark A. Atkinson | Zendy; Shiwu Li | Zendy; Lijun Yang | Zendy

Open Access

Reversal of Streptozotocin-Induced Diabetes in Mice by Cellular Transduction With Recombinant Pancreatic Transcription Factor Pancreatic Duodenal Homeobox-1

Author(s) -

Vijay Koya,

Shun Lu,

Yuping Sun,

Daniel L. Purich,

Mark A. Atkinson,

Shiwu Li,

Lijun Yang

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-1441

Subject(s) - pdx1 , endocrinology , medicine , streptozotocin , pancreas , insulin , biology , diabetes mellitus , islet

The key pancreatic transcription factor pancreatic duodenal homeobox-1 (Pdx1), known to control development and maintenance of pancreatic beta-cells, possesses a protein transduction domain (PTD) that facilitates its entry into cells. We therefore sought to evaluate the capacity of in vivo-administered recombinant Pdx1 (rPdx1) to ameliorate hyperglycemia in mice with streptozotocin-induced diabetes.

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