Different Brain Responses to Hypoglycemia Induced by Equipotent Doses of the Long-Acting Insulin Analog Detemir and Human Regular Insulin in Humans | Zendy

Paolo Rossetti | Zendy; Francesca Porcellati | Zendy; N Ricci | Zendy; Paola Candeloro | Zendy; Patrizia Cioli | Zendy; Geremia B. Bolli | Zendy; Carmine G. Fanelli | Zendy

Open Access

Different Brain Responses to Hypoglycemia Induced by Equipotent Doses of the Long-Acting Insulin Analog Detemir and Human Regular Insulin in Humans

Author(s) -

Paolo Rossetti,

Francesca Porcellati,

N Ricci,

Paola Candeloro,

Patrizia Cioli,

Geremia B. Bolli,

Carmine G. Fanelli

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-1433

Subject(s) - insulin detemir , endocrinology , hypoglycemia , medicine , insulin , glycemic , adrenergic , hormone , diabetes mellitus , human insulin , insulin glargine , receptor

The acylated long-acting insulin analog detemir is more lipophilic than human insulin and likely crosses the blood-to-brain barrier more easily than does human insulin. The aim of these studies was to assess the brain/hypothalamus responses to euglycemia and hypoglycemia in humans during intravenous infusion of equipotent doses of detemir and human insulin.

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