β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans | Zendy

Juris J. Meier | Zendy; Alexandra E. Butler | Zendy; Yoshifumi Saisho | Zendy; Travis Monchamp | Zendy; Ryan Galasso | Zendy; Anil Bhushan | Zendy; Robert A. Rizza | Zendy; Peter C. Butler | Zendy

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β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans

Author(s) -

Juris J. Meier,

Alexandra E. Butler,

Yoshifumi Saisho,

Travis Monchamp,

Ryan Galasso,

Anil Bhushan,

Robert A. Rizza,

Peter C. Butler

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-1369

Subject(s) - cell , cell growth , biology , somatic cell , cell division , endocrinology , physiology , genetics , gene

Little is known about the capacity, mechanisms, or timing of growth in beta-cell mass in humans. We sought to establish if the predominant expansion of beta-cell mass in humans occurs in early childhood and if, as in rodents, this coincides with relatively abundant beta-cell replication. We also sought to establish if there is a secondary growth in beta-cell mass coincident with the accelerated somatic growth in adolescence.

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