Increased Skeletal Muscle Tumor Necrosis Factor-α and Impaired Insulin Signaling Persist in Obese Women With Gestational Diabetes Mellitus 1 Year Postpartum | Zendy

Jacob E. Friedman | Zendy; John P. Kirwan | Zendy; Ming Jing | Zendy; Larraine Presley | Zendy; Patrick M. Catalano | Zendy

Open Access

Increased Skeletal Muscle Tumor Necrosis Factor-α and Impaired Insulin Signaling Persist in Obese Women With Gestational Diabetes Mellitus 1 Year Postpartum

Author(s) -

Jacob E. Friedman,

John P. Kirwan,

Ming Jing,

Larraine Presley,

Patrick M. Catalano

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-1356

Subject(s) - insulin resistance , medicine , endocrinology , gestational diabetes , insulin receptor , insulin , glucose clamp technique , diabetes mellitus , skeletal muscle , postpartum period , type 2 diabetes , pregnancy , gestation , pancreatic hormone , biology , genetics

Women with gestational diabetes mellitus (GDM) demonstrate chronic and progressive insulin resistance and a markedly increased risk of converting to type 2 diabetes after pregnancy. However, the cellular mechanisms underlying this insulin resistance are unknown.

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