Cyclical and Alternating Infusions of Glucose and Intralipid in Rats Inhibit Insulin Gene Expression and Pdx-1 Binding in Islets | Zendy

Derek Hagman | Zendy; Martin G. Latour | Zendy; S. K. Chakrabarti | Zendy; Ghislaine Fontès | Zendy; Julie Amyot | Zendy; Caroline Tremblay | Zendy; Meriem Semache | Zendy; James Lausier | Zendy; Violet Roskens | Zendy; Raghavendra G. Mirmira | Zendy; Thomas L. Jetton | Zendy; Vincent Poitout | Zendy

Open Access

Cyclical and Alternating Infusions of Glucose and Intralipid in Rats Inhibit Insulin Gene Expression and Pdx-1 Binding in Islets

Author(s) -

Derek Hagman,

Martin G. Latour,

S. K. Chakrabarti,

Ghislaine Fontès,

Julie Amyot,

Caroline Tremblay,

Meriem Semache,

James Lausier,

Violet Roskens,

Raghavendra G. Mirmira,

Thomas L. Jetton,

Vincent Poitout

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-1285

Subject(s) - medicine , insulin , endocrinology , islet , gene expression , chemistry , gene , biochemistry

Prolonged exposure of isolated islets of Langerhans to elevated levels of fatty acids, in the presence of high glucose, impairs insulin gene expression via a transcriptional mechanism involving nuclear exclusion of pancreas-duodenum homeobox-1 (Pdx-1) and loss of MafA expression. Whether such a phenomenon also occurs in vivo is unknown. Our objective was therefore to ascertain whether chronic nutrient oversupply inhibits insulin gene expression in vivo.

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