In Vitro Proliferation of Cells Derived From Adult Human β-Cells Revealed By Cell-Lineage Tracing | Zendy

Holger A. Russ | Zendy; Yael Bar | Zendy; Philippe Ravassard | Zendy; Shimon Efrat | Zendy

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In Vitro Proliferation of Cells Derived From Adult Human β-Cells Revealed By Cell-Lineage Tracing

Author(s) -

Holger A. Russ,

Yael Bar,

Philippe Ravassard,

Shimon Efrat

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-1283

Subject(s) - biology , cell culture , microbiology and biotechnology , population , cre recombinase , cellular differentiation , beta cell , transgene , genetically modified mouse , islet , insulin , gene , genetics , endocrinology , medicine , environmental health

Expansion of insulin-producing beta-cells from adult human islets could alleviate donor shortage for cell-replacement therapy of diabetes. A major obstacle to development of effective expansion protocols is the rapid loss of beta-cell markers in the cultured cells. Here, we report a genetic cell-lineage tracing approach for following the fate of cultured beta-cells.

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