PPARGC1A Variation Associated With DNA Damage, Diabetes, and Cardiovascular Diseases | Zendy

ChaoQiang Lai | Zendy; Katherine L. Tucker | Zendy; Laurence D. Parnell | Zendy; Xian Adiconis | Zendy; Bibiana GarcíaBailo | Zendy; John L. Griffith | Zendy; Mohsen Meydani | Zendy; José M. Ordovás | Zendy

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PPARGC1A Variation Associated With DNA Damage, Diabetes, and Cardiovascular Diseases

Author(s) -

ChaoQiang Lai,

Katherine L. Tucker,

Laurence D. Parnell,

Xian Adiconis,

Bibiana GarcíaBailo,

John L. Griffith,

Mohsen Meydani,

José M. Ordovás

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-1238

Subject(s) - ppargc1a , dna damage , type 2 diabetes , coactivator , dna repair , diabetes mellitus , population , odds ratio , medicine , biology , endocrinology , genetics , dna , environmental health , gene , transcription factor

Individuals with type 2 diabetes exhibit higher DNA damage and increased risk of cardiovascular disease (CVD). However, mechanisms underlying the association between DNA damage and development of type 2 diabetes and CVD are not understood. We sought to link peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PPARGC1A), a master transcriptional regulator of mitochondrial oxidative phosphorylation and cellular energy metabolism, with DNA damage, type 2 diabetes, and CVD.

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