Open Access5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy
Author(s) -
Rose GubitosiKlug,
Ramaprasad Ravichandra Talahalli,
Yunpeng Du,
Jerry L. Nadler,
Timothy S. Kern
Publication year - 2008
Publication title -
diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.219
H-Index - 330
eISSN - 1939-327X
pISSN - 0012-1797
DOI - 10.2337/db07-1217
Subject(s) - leukostasis , endocrinology , diabetic retinopathy , medicine , arachidonate 5 lipoxygenase , retinal , biology , lipoxygenase , chemistry , diabetes mellitus , biochemistry , enzyme , arachidonic acid
Lipoxygenases are regulators of chronic inflammation and oxidative stress generation. We evaluated the role of 5- and 12-lipoxygenases in the development of diabetic retinopathy.
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