Inhibition of AMP-Activated Protein Kinase Protects Pancreatic β-Cells From Cytokine-Mediated Apoptosis and CD8+ T-Cell–Induced Cytotoxicity | Zendy

Audrey Riboulet-Chavey | Zendy; Frédérique Diraison | Zendy; L. Khai Siew | Zendy; F. Susan Wong | Zendy; Guy A. Rutter | Zendy

Open Access

Inhibition of AMP-Activated Protein Kinase Protects Pancreatic β-Cells From Cytokine-Mediated Apoptosis and CD8+ T-Cell–Induced Cytotoxicity

Author(s) -

Audrey Riboulet-Chavey,

Frédérique Diraison,

L. Khai Siew,

F. Susan Wong,

Guy A. Rutter

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0993

Subject(s) - ampk , cytotoxic t cell , protein kinase a , apoptosis , pancreatic islets , biology , nod mice , islet , cancer research , amp activated protein kinase , microbiology and biotechnology , chemistry , endocrinology , kinase , insulin , biochemistry , in vitro

Apoptotic destruction of insulin-producing pancreatic beta-cells is involved in the etiology of both type 1 and type 2 diabetes. AMP-activated protein kinase (AMPK) is a sensor of cellular energy charge whose sustained activation has recently been implicated in pancreatic beta-cell apoptosis and in islet cell death posttransplantation. Here, we examine the importance of beta-cell AMPK in cytokine-induced apoptosis and in the cytotoxic action of CD8(+) T-cells.

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