Omentin-1, a Novel Adipokine, Is Decreased in Overweight Insulin-Resistant Women With Polycystic Ovary Syndrome | Zendy

Bee K. Tan | Zendy; Raghu Adya | Zendy; Farhatullah Syed | Zendy; Krzysztof Lewandowski | Zendy; Paul O’Hare | Zendy; Hendrik Lehnert | Zendy; Harpal S. Randeva | Zendy

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Omentin-1, a Novel Adipokine, Is Decreased in Overweight Insulin-Resistant Women With Polycystic Ovary Syndrome

Author(s) -

Bee K. Tan,

Raghu Adya,

Farhatullah Syed,

Krzysztof Lewandowski,

Paul O’Hare,

Hendrik Lehnert,

Harpal S. Randeva

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0990

Subject(s) - medicine , endocrinology , polycystic ovary , adipose tissue , hyperinsulinemia , insulin resistance , adipokine , insulin , ex vivo , in vivo , biology , microbiology and biotechnology

Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. Recent studies have shown that plasma omentin-1 levels decrease with obesity. Currently, no data exist on the relative expression and regulation of omentin-1 in adipose tissue of women with PCOS. The objective of this study was to assess mRNA and protein levels of omentin-1, including circulating omentin-1, in omental adipose tissue of women with PCOS and matched control subjects. Ex vivo and in vivo regulation of adipose tissue omentin-1 was also studied.

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