Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets | Zendy

Luan Shu | Zendy; Nadine S. Sauter | Zendy; Fabienne T. Schulthess | Zendy; Aleksey V. Matveyenko | Zendy; José Oberholzer | Zendy; Kathrin Maedler | Zendy

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Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets

Author(s) -

Luan Shu,

Nadine S. Sauter,

Fabienne T. Schulthess,

Aleksey V. Matveyenko,

José Oberholzer,

Kathrin Maedler

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0847

Subject(s) - tcf7l2 , biology , apoptosis , pancreatic islets , beta cell , endocrinology , small interfering rna , medicine , transcription factor , cancer research , islet , microbiology and biotechnology , insulin , cell culture , gene , biochemistry , transfection , genetics , genotype , single nucleotide polymorphism

Type 2 diabetes is characterized by impaired insulin secretion in response to increased metabolic demand. This defect in beta-cell compensation seems to result from the interplay between environmental factors and genetic predisposition. Genome-wide association studies reveal that common variants in transcription factor 7-like 2 (TCF7L2) are associated with increased risk of type 2 diabetes. The aim of the present study was to establish whether TCF7L2 plays a role in beta-cell function and/or survival.

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