Liver-Specific Peroxisome Proliferator–Activated Receptor α Target Gene Regulation by the Angiotensin Type 1 Receptor Blocker Telmisartan | Zendy

Markus Clemenz | Zendy; Nikolaj Frost | Zendy; Michael Schupp | Zendy; Sandrine Caron | Zendy; Anna ForystLudwig | Zendy; Christian Böhm | Zendy; Martin Hartge | Zendy; Ronald Gust | Zendy; Bart Staels | Zendy; Thomas Unger | Zendy; Ulrich Kintscher | Zendy

Open Access

Liver-Specific Peroxisome Proliferator–Activated Receptor α Target Gene Regulation by the Angiotensin Type 1 Receptor Blocker Telmisartan

Author(s) -

Markus Clemenz,

Nikolaj Frost,

Michael Schupp,

Sandrine Caron,

Anna ForystLudwig,

Christian Böhm,

Martin Hartge,

Ronald Gust,

Bart Staels,

Thomas Unger,

Ulrich Kintscher

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0839

Subject(s) - telmisartan , endocrinology , peroxisome proliferator activated receptor , medicine , transactivation , receptor , angiotensin ii , gene knockdown , agonist , chemistry , biology , gene expression , biochemistry , gene , blood pressure

The angiotensin type 1 receptor blocker (ARB) and peroxisome proliferator-activated receptor (PPAR) gamma modulator telmisartan has been recently demonstrated to reduce plasma triglycerides in nondiabetic and diabetic hypertensive patients. The present study investigates the molecular mechanisms of telmisartans hypolipidemic actions, in particular its effect on the PPARalpha pathway. RESEARCH DESIGN AND METHODS; Regulation of PPARalpha target genes by telmisartan was studied by real-time PCR and Western immunoblotting in vitro and in vivo in liver/skeletal muscle of mice with diet-induced obesity. Activation of the PPARalpha ligand binding domain (LBD) was investigated using transactivation assays.

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