Open AccessInactivation of Glyceraldehyde-3-Phosphate Dehydrogenase by Fumarate in Diabetes
Author(s) -
Matthew Blatnik,
Norma Frizzell,
Suzanne R. Thorpe,
John Baynes
Publication year - 2007
Publication title -
diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.219
H-Index - 330
eISSN - 1939-327X
pISSN - 0012-1797
DOI - 10.2337/db07-0838
Subject(s) - glyceraldehyde 3 phosphate dehydrogenase , chemistry , dehydrogenase , glyceraldehyde , biochemistry , in vitro , enzyme , in vivo , chromatography , biology , microbiology and biotechnology
(2-succinyl)cysteine (2SC) is formed by a Michael addition reaction of the Krebs cycle intermediate, fumarate, with cysteine residues in protein. We investigated the role of fumarate in chemical modification and inhibition of the sulfhydryl enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), in vitro and in tissues of diabetic rats.
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