Nonobese Diabetic (NOD) Mice Congenic for a Targeted Deletion of 12/15-Lipoxygenase Are Protected From Autoimmune Diabetes | Zendy

Marcia McDuffie | Zendy; Nelly A. Maybee | Zendy; Susanna R. Keller | Zendy; Brian K. Stevens | Zendy; James C. Garmey | Zendy; Margaret Morris | Zendy; Elizabeth Kropf | Zendy; Claudia Rival | Zendy; Kaiwen Ma | Zendy; Jeffrey D. Carter | Zendy; Sarah A. Tersey | Zendy; Craig S. Nunemaker | Zendy; Jerry L. Nadler | Zendy

Open Access

Nonobese Diabetic (NOD) Mice Congenic for a Targeted Deletion of 12/15-Lipoxygenase Are Protected From Autoimmune Diabetes

Author(s) -

Marcia McDuffie,

Nelly A. Maybee,

Susanna R. Keller,

Brian K. Stevens,

James C. Garmey,

Margaret Morris,

Elizabeth Kropf,

Claudia Rival,

Kaiwen Ma,

Jeffrey D. Carter,

Sarah A. Tersey,

Craig S. Nunemaker,

Jerry L. Nadler

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0830

Subject(s) - congenic , nod , autoimmune diabetes , nod mice , diabetes mellitus , immunology , autoimmunity , medicine , lipoxygenase , autoimmune disease , endocrinology , biology , type 1 diabetes , antibody , enzyme , genetics , biochemistry , gene

12/15-lipoxygenase (12/15-LO), one of a family of fatty acid oxidoreductase enzymes, reacts with polyenoic fatty acids to produce proinflammatory lipids. 12/15-LO is expressed in macrophages and pancreatic beta-cells. It enhances interleukin 12 production by macrophages, and several of its products induce apoptosis of beta-cells at nanomolar concentrations in vitro. We had previously demonstrated a role for 12/15-LO in beta-cell damage in the streptozotocin model of diabetes. Since the gene encoding 12/15-LO (gene designation Alox15) lies within the Idd4 diabetes susceptibility interval in NOD mice, we hypothesized that 12/15-LO is also a key regulator of diabetes susceptibility in the NOD mouse.

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