Nephropathy in Type 1 Diabetes Is Diminished in Carriers of HLA-DRB1*04 | Zendy

Suzanne K. Cordovado | Zendy; Yuan Zhao | Zendy; James H. Warram | Zendy; Hongguang Gong | Zendy; Karen Anderson | Zendy; Miyono Hendrix | Zendy; Laura Hancock | Zendy; Patricia A. Cleary | Zendy; Patricia W. Mueller | Zendy

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Nephropathy in Type 1 Diabetes Is Diminished in Carriers of HLA-DRB1*04

Author(s) -

Suzanne K. Cordovado,

Yuan Zhao,

James H. Warram,

Hongguang Gong,

Karen Anderson,

Miyono Hendrix,

Laura Hancock,

Patricia A. Cleary,

Patricia W. Mueller

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0826

Subject(s) - medicine , human leukocyte antigen , diabetes mellitus , type 2 diabetes , nephropathy , diabetic nephropathy , type 1 diabetes , immunology , endocrinology , antigen

The purpose of this study was to examine whether known genetic risk factors for type 1 diabetes (HLA-DRB1, -DQA1, and -DQB1 and insulin locus) play a role in the etiology of diabetic nephropathy. RESEARCH DESIGN AND METHODS; Genetic analysis of HLA-DRB1, -DQA1, -DQB1 and the insulin gene (INS) was performed in the Genetics of Kidneys in Diabetes (GoKinD) collection of DNA (European ancestry subset), which includes case patients with type 1 diabetes and nephropathy (n = 829) and control patients with type 1 diabetes but not nephropathy (n = 904). The availability of phenotypic and genotypic data on GoKinD participants allowed a detailed analysis of the association of these genes with diabetic nephropathy.

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