Evidence of Increased Inflammation and Microcirculatory Abnormalities in Patients With Type 1 Diabetes and Their Role in Microvascular Complications | Zendy

Sridevi Devaraj | Zendy; Anthony Cheung | Zendy; Ishwarlal Jialal | Zendy; Steven C. Griffen | Zendy; Danh V. Nguyen | Zendy; Nicole Glaser | Zendy; Thomas T. Aoki | Zendy

Open Access

Evidence of Increased Inflammation and Microcirculatory Abnormalities in Patients With Type 1 Diabetes and Their Role in Microvascular Complications

Author(s) -

Sridevi Devaraj,

Anthony Cheung,

Ishwarlal Jialal,

Steven C. Griffen,

Danh V. Nguyen,

Nicole Glaser,

Thomas T. Aoki

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0784

Subject(s) - type 1 diabetes , medicine , inflammation , diabetic angiopathy , endocrinology , type 2 diabetes , diabetes mellitus , c reactive protein , superoxide , monocyte , gastroenterology , chemistry , biochemistry , enzyme

Type 1 diabetes is associated with increased microvascular complications and inflammation. The monocyte-macrophage is a pivotal cell in atherogenesis. There are scanty data on noninvasive measures of microvascular abnormalities and inflammation in type 1 diabetic subjects with microvascular complications. Thus, we examined systemic and cellular biomarkers of inflammation in type 1 diabetic patients with microvascular complications (T1DM-MV patients) and type 1 diabetic patients without microvascular complications (T1DM patients) compared with matched control subjects and determined the microcirculatory abnormalities in the T1DM and T1DM-MV patients using computer-assisted intravital microscopy (CAIM).

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