Elevated Epidermal Growth Factor Receptor Phosphorylation Induces Resistance Artery Dysfunction in Diabetic db/db Mice | Zendy

Souad Belmadani | Zendy; Desiree I. Palen | Zendy; Romer A. GonzalezVillalobos | Zendy; Hamid Boulares | Zendy; Khalid Matrougui | Zendy

Open Access

Elevated Epidermal Growth Factor Receptor Phosphorylation Induces Resistance Artery Dysfunction in Diabetic db/db Mice

Author(s) -

Souad Belmadani,

Desiree I. Palen,

Romer A. GonzalezVillalobos,

Hamid Boulares,

Khalid Matrougui

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0739

Subject(s) - medicine , endocrinology , enos , endothelial dysfunction , phosphorylation , endothelium , nitric oxide , nitric oxide synthase , biology , microbiology and biotechnology

We previously showed epidermal growth factor receptor (EGFR) transactivation to be key mechanism in the regulation of resistance artery myogenic tone. Type 2 diabetes is associated with microvascular complications. We hypothesized that elevated EGFR phosphorylation contributes to resistance artery dysfunction in type 2 diabetes.

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