Association of the Vitamin D Metabolism Gene CYP27B1 With Type 1 Diabetes | Zendy

Rebecca Bailey | Zendy; Jason D. Cooper | Zendy; Lauren R Zeitels | Zendy; Deborah J. Smyth | Zendy; Jennie H. M. Yang | Zendy; Neil Walker | Zendy; Elina Hyppönen | Zendy; David B. Dunger | Zendy; Elizabeth RamosLopez | Zendy; Klaus Badenhoop | Zendy; Sergey Nejentsev | Zendy; John A. Todd | Zendy

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Association of the Vitamin D Metabolism Gene CYP27B1 With Type 1 Diabetes

Author(s) -

Rebecca Bailey,

Jason D. Cooper,

Lauren R Zeitels,

Deborah J. Smyth,

Jennie H. M. Yang,

Neil Walker,

Elina Hyppönen,

David B. Dunger,

Elizabeth RamosLopez,

Klaus Badenhoop,

Sergey Nejentsev,

John A. Todd

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0652

Subject(s) - type 2 diabetes , vitamin d and neurology , endocrinology , medicine , diabetes mellitus , association (psychology) , biology , psychology , psychotherapist

Epidemiological studies have linked vitamin D deficiency with the susceptibility to type 1 diabetes. Higher levels of the active metabolite 1 alpha,25-dihydroxyvitamin D (1 alpha,25(OH)(2)D) could protect from immune destruction of the pancreatic beta-cells. 1 alpha,25(OH)(2)D is derived from its precursor 25-hydroxyvitamin D by the enzyme 1 alpha-hydroxylase encoded by the CYP27B1 gene and is inactivated by 24-hydroxylase encoded by the CYP24A1 gene. Our aim was to study the association between the CYP27B1 and CYP24A1 gene polymorphisms and type 1 diabetes.

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