Inhibition of Foxo1 Protects Pancreatic Islet β-Cells Against Fatty Acid and Endoplasmic Reticulum Stress–Induced Apoptosis | Zendy

Sara C. Martinez | Zendy; Katsuya Tanabe | Zendy; Corentin CrasMéneur | Zendy; Nada A. Abumrad | Zendy; Ernesto BernalMizrachi | Zendy; M. Alan Permutt | Zendy

Open Access

Inhibition of Foxo1 Protects Pancreatic Islet β-Cells Against Fatty Acid and Endoplasmic Reticulum Stress–Induced Apoptosis

Author(s) -

Sara C. Martinez,

Katsuya Tanabe,

Corentin CrasMéneur,

Nada A. Abumrad,

Ernesto BernalMizrachi,

M. Alan Permutt

Publication year - 2008

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0595

Subject(s) - foxo1 , unfolded protein response , endoplasmic reticulum , apoptosis , protein kinase b , fatty acid , endocrinology , kinase , medicine , biology , signal transduction , chemistry , microbiology and biotechnology , biochemistry

beta-Cells are particularly susceptible to fatty acid-induced apoptosis associated with decreased insulin receptor/phosphatidylinositol-3 kinase/Akt signaling and the activation of stress kinases. We examined the mechanism of fatty acid-induced apoptosis of mouse beta-cells especially as related to the role played by endoplasmic reticulum (ER) stress-induced Foxo1 activation and whether decreasing Foxo1 activity could enhance cell survival.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research