A Microsphere-Based Vaccine Prevents and Reverses New-Onset Autoimmune Diabetes
Author(s) -
Brett E. Phillips,
Karen D. Nylander,
Jo Harnaha,
Jennifer Machen,
Robert Lakomy,
Alexis Styche,
Kimberly Gillis,
L. R. Brown,
Debra Lafreniere,
Michael Gallo,
Janet Knox,
Kenneth Hogeland,
Massimo Trucco,
Nick Giannoukakis
Publication year - 2008
Publication title -
diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.219
H-Index - 330
eISSN - 1939-327X
pISSN - 0012-1797
DOI - 10.2337/db07-0507
Subject(s) - nod mice , foxp3 , nod , cd80 , splenocyte , spleen , immunology , medicine , adoptive cell transfer , immune system , cd86 , t cell , antigen , diabetes mellitus , cd40 , biology , endocrinology , cytotoxic t cell , autoimmunity , in vitro , biochemistry
This study was aimed at ascertaining the efficacy of antisense oligonucleotide-formulated microspheres to prevent type 1 diabetes and to reverse new-onset disease.
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