Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E–Deficient Mice | Zendy

Susanna M. Hofmann | Zendy; Diego Pérez–Tilve | Zendy; Todd M. Greer | Zendy; Beth A. Coburn | Zendy; Erin Grant | Zendy; Joshua E. Basford | Zendy; Matthias H. Tschöp | Zendy; David Y. Hui | Zendy

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Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E–Deficient Mice

Author(s) -

Susanna M. Hofmann,

Diego Pérez–Tilve,

Todd M. Greer,

Beth A. Coburn,

Erin Grant,

Joshua E. Basford,

Matthias H. Tschöp,

David Y. Hui

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0403

Subject(s) - endocrinology , medicine , apolipoprotein e , triglyceride , adipose tissue , biology , insulin , diet induced obese , brown adipose tissue , lipolysis , insulin resistance , cholesterol , disease

Apolipoprotein E (ApoE) regulates plasma lipid levels via modulation of lipolysis and serving as ligand for receptor-mediated clearance of triglyceride (TG)-rich lipoproteins. This study tested the impact of modulating lipid delivery to tissues on insulin responsiveness and diet-induced obesity.

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