Effect of Insulin Deprivation on Muscle Mitochondrial ATP Production and Gene Transcript Levels in Type 1 Diabetic Subjects | Zendy

Helen Karakelides | Zendy; Yan W. Asmann | Zendy; Maureen L. Bigelow | Zendy; Kevin R. Short | Zendy; Ketan Dhatariya | Zendy; Jill M. Coenen-Schimke | Zendy; Jane Kahl | Zendy; Debabrata Mukhopadhyay | Zendy; K. Sreekumaran Nair | Zendy

Open Access

Effect of Insulin Deprivation on Muscle Mitochondrial ATP Production and Gene Transcript Levels in Type 1 Diabetic Subjects

Author(s) -

Helen Karakelides,

Yan W. Asmann,

Maureen L. Bigelow,

Kevin R. Short,

Ketan Dhatariya,

Jill M. Coenen-Schimke,

Jane Kahl,

Debabrata Mukhopadhyay,

K. Sreekumaran Nair

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0378

Subject(s) - endocrinology , medicine , gene , insulin , biology , mitochondrial dna , type 2 diabetes , mitochondrion , diabetes mellitus , genetics

Muscle mitochondrial dysfunction occurs in many insulin-resistant states, such as type 2 diabetes, prompting a hypothesis that mitochondrial dysfunction may cause insulin resistance. We determined the impact of insulin deficiency on muscle mitochondrial ATP production by temporarily depriving type 1 diabetic patients of insulin treatment.

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