Further Evidence of a Primary, Causal Association of the PTPN22 620W Variant With Type 1 Diabetes | Zendy

Magdalena Żołędziewska | Zendy; Chiara Perra | Zendy; Valeria Orrù | Zendy; Loredana Moi | Zendy; Paola Frongia | Zendy; Mauro Congia | Zendy; Nunzio Bottini | Zendy; Francesco Cucca | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Further Evidence of a Primary, Causal Association of the PTPN22 620W Variant With Type 1 Diabetes

Author(s) -

Magdalena Żołędziewska,

Chiara Perra,

Valeria Orrù,

Loredana Moi,

Paola Frongia,

Mauro Congia,

Nunzio Bottini,

Francesco Cucca

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0289

Subject(s) - ptpn22 , association (psychology) , type 2 diabetes , medicine , diabetes mellitus , psychology , genetics , biology , endocrinology , genotype , psychotherapist , single nucleotide polymorphism , gene

The minor allele of the nonsynonymous single nucleotide polymorphism (SNP) +1858C>T within the PTPN22 gene is positively associated with type 1 diabetes and other autoimmune diseases. Genetic and functional data underline its causal effect, but some studies suggest that this polymorphism does not entirely explain disease association of the PTPN22 region. The aim of this study was to evaluate type 1 diabetes association within this gene in the Sardinian population.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research