Selective Downregulation of the High–Molecular Weight Form of Adiponectin in Hyperinsulinemia and in Type 2 Diabetes | Zendy

Rita Basu | Zendy; Utpal B. Pajvani | Zendy; Robert A. Rizza | Zendy; Philipp E. Scherer | Zendy

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Selective Downregulation of the High–Molecular Weight Form of Adiponectin in Hyperinsulinemia and in Type 2 Diabetes

Author(s) -

Rita Basu,

Utpal B. Pajvani,

Robert A. Rizza,

Philipp E. Scherer

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-0185

Subject(s) - adiponectin , hyperinsulinemia , medicine , endocrinology , diabetes mellitus , insulin , type 2 diabetes , splanchnic , basal (medicine) , adipocyte , insulin resistance , adipose tissue , hemodynamics

Adiponectin is an adipocyte-specific secretory protein found in circulation in several different forms and is present at significantly lower levels in the plasma of diabetic patients compared with that of insulin-sensitive individuals. We wanted to test whether insulin per se is a contributing factor toward lower plasma adiponectin concentrations and, if so, whether the splanchnic bed contributes to this phenomenon.

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