A Novel Susceptibility Locus on Rat Chromosome 8 Affects Spontaneous but Not Experimentally Induced Type 1 Diabetes | Zendy

Robert H. Wallis | Zendy; Kesheng Wang | Zendy; Dominika Dabrowski | Zendy; Leili Marandi | Zendy; Terri Ning | Zendy; Eugene Hsieh | Zendy; Andrew D. Paterson | Zendy; John P. Mordes | Zendy; Elisabeth P. Blankenhorn | Zendy; Philippe Poussier | Zendy

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A Novel Susceptibility Locus on Rat Chromosome 8 Affects Spontaneous but Not Experimentally Induced Type 1 Diabetes

Author(s) -

Robert H. Wallis,

Kesheng Wang,

Dominika Dabrowski,

Leili Marandi,

Terri Ning,

Eugene Hsieh,

Andrew D. Paterson,

John P. Mordes,

Elisabeth P. Blankenhorn,

Philippe Poussier

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db06-1790

Subject(s) - congenic , locus (genetics) , allele , genetics , biology , type 2 diabetes , diabetes mellitus , insulitis , chromosome , genetic linkage , immunology , endocrinology , type 1 diabetes , gene

The biobreeding diabetes-prone (BBDP) rat spontaneously develops type 1 diabetes. Two of the genetic factors contributing to this syndrome are the major histocompatibility complex (Iddm1) and a Gimap5 mutation (Iddm2) responsible for a T-lymphopenia. Susceptibility to experimentally induced type 1 diabetes is widespread among nonlymphopenic (wild-type Iddm2) rat strains provided they share the BBDP Iddm1 allele. The question follows as to whether spontaneous and experimentally induced type 1 diabetes share susceptibility loci besides Iddm1. Our objectives were to map a novel, serendipitously discovered Iddm locus, confirm its effects by developing congenic sublines, and assess its differential contribution to spontaneous and experimentally induced type 1 diabetes.

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