Proteolytic Degradation of VE-Cadherin Alters the Blood-Retinal Barrier in Diabetes | Zendy

Deepti Navaratna | Zendy; Paul McGuire | Zendy; G. Menicucci | Zendy; Arup Das | Zendy

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Proteolytic Degradation of VE-Cadherin Alters the Blood-Retinal Barrier in Diabetes

Author(s) -

Deepti Navaratna,

Paul McGuire,

G. Menicucci,

Arup Das

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db06-1694

Subject(s) - adherens junction , ve cadherin , vascular permeability , blood–retinal barrier , retinal , diabetes mellitus , matrix metalloproteinase , evans blue , endothelial stem cell , endocrinology , cadherin , microbiology and biotechnology , medicine , biology , diabetic retinopathy , cell , biochemistry , in vitro

Increased vascular permeability due to alteration of the blood-retinal barrier (BRB) is one of the major complications in early diabetes. The aim of the present study was to determine whether diabetes alters the cellular expression and distribution of the adherens junction protein vascular endothelial (VE)-cadherin in retinal endothelial cells and if this alteration is mediated by proteinase activity.

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