Transcription Factor 7-Like 2 (TCF7L2) Is Associated With Gestational Diabetes Mellitus and Interacts With Adiposity to Alter Insulin Secretion in Mexican Americans | Zendy

Richard M. Watanabe | Zendy; Hooman Allayee | Zendy; Anny H. Xiang | Zendy; Enrique Trigo | Zendy; Jaana Hartiala | Zendy; Jean M. Lawrence | Zendy; Thomas A. Buchanan | Zendy

Open Access

Transcription Factor 7-Like 2 (TCF7L2) Is Associated With Gestational Diabetes Mellitus and Interacts With Adiposity to Alter Insulin Secretion in Mexican Americans

Author(s) -

Richard M. Watanabe,

Hooman Allayee,

Anny H. Xiang,

Enrique Trigo,

Jaana Hartiala,

Jean M. Lawrence,

Thomas A. Buchanan

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db06-1682

Subject(s) - medicine , endocrinology , gestational diabetes , single nucleotide polymorphism , tcf7l2 , diabetes mellitus , insulin resistance , insulin , type 2 diabetes , biology , pregnancy , genotype , gestation , genetics , gene

Variation in transcription factor 7-like 2 (TCF7L2) gene has been shown to be associated with type 2 diabetes and diabetes-related quantitative traits. We examined variation in a 0.1-Mb region surrounding marker DG10S478 for association with diabetes-related quantitative traits in 132 Mexican-American families of a proband with previous gestational diabetes mellitus (GDM).

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