High-Fat Diet–Induced Neuropathy of Pre-Diabetes and Obesity | Zendy

Irina G. Obrosova | Zendy; Olga Ilnytska | Zendy; Valeriy V. Lyzogubov | Zendy; Ivan Pavlov | Zendy; Nazar Mashtalir | Zendy; Jerry L. Nadler | Zendy; Viktor R. Drel | Zendy

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High-Fat Diet–Induced Neuropathy of Pre-Diabetes and Obesity

Author(s) -

Irina G. Obrosova,

Olga Ilnytska,

Valeriy V. Lyzogubov,

Ivan Pavlov,

Nazar Mashtalir,

Jerry L. Nadler,

Viktor R. Drel

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db06-1176

Subject(s) - endocrinology , medicine , hypoalgesia , peripheral neuropathy , diabetes mellitus , diabetic neuropathy , dorsal root ganglion , allodynia , nerve conduction velocity , hyperalgesia , impaired glucose tolerance , type 2 diabetes , nociception , anatomy , receptor , dorsum

Subjects with dietary obesity and pre-diabetes have an increased risk for developing both nerve conduction slowing and small sensory fiber neuropathy. Animal models of this type of neuropathy have not been described. This study evaluated neuropathic changes and their amenability to dietary and pharmacological interventions in mice fed a high-fat diet (HFD), a model of pre-diabetes and alimentary obesity.

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