Effects of the Renin-Angiotensin System Genes and Salt Sensitivity Genes on Blood Pressure and Atherosclerosis in the Total Population and Patients With Type 2 Diabetes | Zendy

Mojgan Yazdanpanah | Zendy; Yurii S. Aulchenko | Zendy; Albert Hofman | Zendy; J. A. M. J. L. Janssen | Zendy; Fakhredin A. SayedTabatabaei | Zendy; Ron H. N. van Schaik | Zendy; Olaf H. Klungel | Zendy; Bruno H. Stricker | Zendy; Huibert A. P. Pols | Zendy; Jacqueline C.M. Witteman | Zendy; Steven W. J. Lamberts | Zendy; Ben A. Oostra | Zendy; Cornelia M. van Duijn | Zendy

Open Access

Effects of the Renin-Angiotensin System Genes and Salt Sensitivity Genes on Blood Pressure and Atherosclerosis in the Total Population and Patients With Type 2 Diabetes

Author(s) -

Mojgan Yazdanpanah,

Yurii S. Aulchenko,

Albert Hofman,

J. A. M. J. L. Janssen,

Fakhredin A. SayedTabatabaei,

Ron H. N. van Schaik,

Olaf H. Klungel,

Bruno H. Stricker,

Huibert A. P. Pols,

Jacqueline C.M. Witteman,

Steven W. J. Lamberts,

Ben A. Oostra,

Cornelia M. van Duijn

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db06-1127

Subject(s) - blood pressure , pulse pressure , type 2 diabetes , medicine , diabetes mellitus , genotype , population , rotterdam study , endocrinology , renin–angiotensin system , candidate gene , cardiology , gene , biology , genetics , cohort study , environmental health

Most studies on the genetic determinants of blood pressure and vascular complications of type 2 diabetes have focused on the effects of single genes. These studies often have yielded conflicting results. Therefore, we examined the combined effects of three renin-angiotensin system (RAS) genes and three salt sensitivity genes in relation to blood pressure and atherosclerosis in the total population and type 2 diabetic patients. The study was a part of the Rotterdam Study, a population-based cohort study. We have genotyped three RAS gene polymorphisms and three salt sensitivity gene polymorphisms. Diabetic patients with three risk genotypes of the RAS genes had a 6.9 mmHg higher systolic blood pressure (P for trend = 0.04) and a 6.0 mmHg higher pulse pressure (P for trend = 0.03) than those who did not carry any risk genotypes. Diabetic patients with three risk genotypes of the salt sensitivity genes had a 9.0 mmHg higher systolic blood pressure (P = 0.19) and a 13.1 mmHg higher pulse pressure (P = 0.02). Diabetic patients who carried three risk genotypes for the RAS genes had a higher mean intima-media thickness than those with two risk genotypes (mean difference 0.04 mm, P = 0.02). We found that among type 2 diabetic patients, mean systolic blood pressure, pulse pressure, and risk of hypertension increased with the number of risk genotypes for the RAS genes and the salt sensitivity genes.

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