IL6 Gene Promoter Polymorphisms and Type 2 Diabetes | Zendy

Cornelia Huth | Zendy; Iris M. Heid | Zendy; Caren Vollmert | Zendy; Christian Gieger | Zendy; Harald Grallert | Zendy; Johanna K. Wolford | Zendy; Birgit Langer | Zendy; Barbara Thorand | Zendy; Norman Klopp | Zendy; Yasmin H. Hamid | Zendy; Oluf Pedersen | Zendy; Torben Hansen | Zendy; Valeriya Lyssenko | Zendy; Leif Groop | Zendy; Christa Meisinger | Zendy; Angela Döring | Zendy; Hannelore Löwel | Zendy; Wolfgang Lieb | Zendy; Christian Hengstenberg | Zendy; Wolfgang Rathmann | Zendy; Stéphan Martin | Zendy; Jeffrey W. Stephens | Zendy; Helen Ireland | Zendy; Hugh M Mather | Zendy; George J. Miller | Zendy; Heather M. Stringham | Zendy; Michael Boehnke | Zendy; Jaakko Tuomilehto | Zendy; Heiner Boeing | Zendy; Matthias Möhlig | Zendy; Joachim Spranger | Zendy; A. Pfeiffer | Zendy; Ingrid Wernstedt Asterholm | Zendy; Anders Niklason | Zendy; Abel LópezBermejo | Zendy; José Manuel FernándezReal | Zendy; Robert L. Hanson | Zendy; Luis Gallart | Zendy; Joan Vendrell | Zendy; Anastasia Tsiavou | Zendy; Erifili Hatziagelaki | Zendy; Steve E. Humphries | Zendy; H.Erich Wichmann | Zendy; Christian Herder | Zendy; Thomas Illig | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

IL6 Gene Promoter Polymorphisms and Type 2 Diabetes

Author(s) -

Cornelia Huth,

Iris M. Heid,

Caren Vollmert,

Christian Gieger,

Harald Grallert,

Johanna K. Wolford,

Birgit Langer,

Barbara Thorand,

Norman Klopp,

Yasmin H. Hamid,

Oluf Pedersen,

Torben Hansen,

Valeriya Lyssenko,

Leif Groop,

Christa Meisinger,

Angela Döring,

Hannelore Löwel,

Wolfgang Lieb,

Christian Hengstenberg,

Wolfgang Rathmann,

Stéphan Martin,

Jeffrey W. Stephens,

Helen Ireland,

Hugh M Mather,

George J. Miller,

Heather M. Stringham,

Michael Boehnke,

Jaakko Tuomilehto,

Heiner Boeing,

Matthias Möhlig,

Joachim Spranger,

A. Pfeiffer,

Ingrid Wernstedt Asterholm,

Anders Niklason,

Abel LópezBermejo,

José Manuel FernándezReal,

Robert L. Hanson,

Luis Gallart,

Joan Vendrell,

Anastasia Tsiavou,

Erifili Hatziagelaki,

Steve E. Humphries,

H.Erich Wichmann,

Christian Herder,

Thomas Illig

Publication year - 2006

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db06-0600

Subject(s) - type 2 diabetes , odds ratio , diabetes mellitus , allele , genotype , medicine , tcf7l2 , interleukin 6 , type 1 diabetes , gene , endocrinology , single nucleotide polymorphism , genetics , biology , cytokine

Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G>C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research