Linkage but Not Association of Calpain-10 to Type 2 Diabetes Replicated in Northern Sweden | Zendy

Elísabet Einarsdóttir | Zendy; Sofia Mayans | Zendy; Karin Ruikka | Zendy; Stefan Andersson Escher | Zendy; Petter Lindgren | Zendy; Åsa Ågren | Zendy; Mats Eliasson | Zendy; Dan Holmberg | Zendy

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Linkage but Not Association of Calpain-10 to Type 2 Diabetes Replicated in Northern Sweden

Author(s) -

Elísabet Einarsdóttir,

Sofia Mayans,

Karin Ruikka,

Stefan Andersson Escher,

Petter Lindgren,

Åsa Ågren,

Mats Eliasson,

Dan Holmberg

Publication year - 2006

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db05-1495

Subject(s) - linkage (software) , genetics , type 2 diabetes , single nucleotide polymorphism , population , genetic association , biology , genetic linkage , odds ratio , cohort , gene , diabetes mellitus , genotype , medicine , endocrinology , environmental health

We present data from a genome-wide scan identifying genetic factors conferring susceptibility to type 2 diabetes. The linkage analysis was based on 59 families from northern Sweden, consisting of a total of 129 cases of type 2 diabetes and 19 individuals with impaired glucose tolerance. Model-free linkage analysis revealed a maximum multipoint logarithm of odds score of 3.19 for D2S2987 at 267.7 cM (P = 0.00058), suggesting that a gene conferring susceptibility to type 2 diabetes in the northern Swedish population resides in the 2q37 region. These data replicate, in a European population, previously identified linkage of marker loci in this region to type 2 diabetes in Mexican Americans. In contrast, no evidence in support of association to the previously identified single nucleotide polymorphisms in the calpain-10 gene was observed in a case-control cohort derived from the same population.

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