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Success of Direct-Acting, Antiviral-Based Therapy for Chronic Hepatitis C Is Not Affected by Type 2 Diabetes
Author(s) -
Blake Niccum,
Jonathan G. Stine,
Javelle A. Wynter,
Virginia Kelly,
Stephen H. Caldwell,
Neeral L. Shah
Publication year - 2019
Publication title -
clinical diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.931
H-Index - 37
eISSN - 1945-4953
pISSN - 0891-8929
DOI - 10.2337/cd18-0112
Subject(s) - medicine , type 2 diabetes , hepatitis c virus , diabetes mellitus , chronic hepatitis , hepatitis c , interferon , antiviral therapy , combination therapy , immunology , virus , endocrinology
Chronic hepatitis C virus (HCV) is a risk factor for type 2 diabetes. In the era of interferon-based HCV therapy, type 2 diabetes was associated with decreased likelihood of sustained virologic response (SVR). Preliminary studies suggest that type 2 diabetes may not reduce the efficacy of regimens involving direct-acting antiviral (DAA) medications. We aimed to determine whether preexisting type 2 diabetes is associated with a reduced rate of SVR achieved 12 weeks after treatment of HCV with DAA-based regimens.

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