Optimization of [ 11 C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image Quantification | Zendy

Èlia Torrent Llongarriu | Zendy; Magı́ Farré | Zendy; Ibane Abasolo | Zendy; Olga Millán | Zendy; Jordi Llop | Zendy; Juan Domingo Gispert | Zendy; Alba Ruiz | Zendy; Deborah Pareto | Zendy

Open Access

Optimization of [ ¹¹ C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image Quantification

Author(s) -

Èlia Torrent Llongarriu,

Magı́ Farré,

Ibane Abasolo,

Olga Millán,

Jordi Llop,

Juan Domingo Gispert,

Alba Ruiz,

Deborah Pareto

Publication year - 2013

Publication title -

molecular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.815

H-Index - 60

eISSN - 1536-0121

pISSN - 1535-3508

DOI - 10.2310/7290.2012.00040

Subject(s) - raclopride , positron emission tomography , nuclear medicine , positron , binding potential , iterative reconstruction , chemistry , physics , mathematics , artificial intelligence , computer science , medicine , receptor , nuclear physics , biochemistry , antagonist , electron

The goal of this study was to compare different quantification approaches and reconstruction methods to estimate the binding potential in [11C]raclopride studies in rats. The final aim was to determine if the results obtained with short-acquisition scanning were comparable to the results obtained with long-acquistion (conventional) scanning. We analyzed two rat data sets: a baseline versus a pretreatment study (with cold raclopride) and a young versus an old animal group comparison. The study results support the contention that optimization of [11C]raclopride positron emission tomographic studies in rats by shortening the acquisition time is feasible. In addition, filtered backprojection is recommended as a reconstruction algorithm, although iterative methods may be more sensitive to detect within-group differences

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