In Vivo Evidence That the Increase in Matrix Metalloproteinase Activity Occurs Early after Cerebral Ischemia | Zendy

Abraham Martín | Zendy; Anikitos Garofalakis | Zendy; Bertrand Tavitian | Zendy

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In Vivo Evidence That the Increase in Matrix Metalloproteinase Activity Occurs Early after Cerebral Ischemia

Author(s) -

Abraham Martín,

Anikitos Garofalakis,

Bertrand Tavitian

Publication year - 2012

Publication title -

molecular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.815

H-Index - 60

eISSN - 1536-0121

pISSN - 1535-3508

DOI - 10.2310/7290.2011.00023

Subject(s) - matrix metalloproteinase , ischemia , in vivo , ex vivo , medicine , ischemic stroke , therapeutic window , stroke (engine) , brain ischemia , cardiology , anesthesia , pharmacology , biology , mechanical engineering , microbiology and biotechnology , engineering

There is controversy over whether matrix metalloproteinases (MMPs) are activated during the early therapeutic window following ischemic stroke. Ex vivo, an increase was reported as early as 4 hours, whereas in vivo, no increase was found until 24 hours postischemia. We used fluorescence diffuse optical tomography to image MMP activity following experimental cerebral ischemia; increased MMP activity was observed in the ischemic area as early as 3 to 6 hours after ischemic onset and correlated with the volume of ischemic cerebral tissue. Therefore, MMP activation is an immediate early response to cerebral ischemia concurrent with the therapeutic window

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