Topical Vapocoolant Quickly and Effectively Reduces Vaccine-associated Pain: Results of a Randomized, Single-blinded, Placebo-controlled Study | Zendy

Steven D. Mawhorter | Zendy; Lynda Daugherty | Zendy; Allison Ford | Zendy; Robin Hughes | Zendy; Dee Metzger | Zendy; Kirk A. Easley | Zendy

Open Access

Topical Vapocoolant Quickly and Effectively Reduces Vaccine-associated Pain: Results of a Randomized, Single-blinded, Placebo-controlled Study

Author(s) -

Steven D. Mawhorter,

Lynda Daugherty,

Allison Ford,

Robin Hughes,

Dee Metzger,

Kirk A. Easley

Publication year - 2006

Publication title -

journal of travel medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.985

H-Index - 59

eISSN - 1708-8305

pISSN - 1195-1982

DOI - 10.2310/7060.2004.19101

Subject(s) - medicine , placebo , anesthesia , topical anesthetic , lidocaine , randomized controlled trial , saline , local anesthetic , visual analogue scale , surgery , alternative medicine , pathology

Comprehensive international travel preparation often requires several vaccines. Up to 90% of adults have some fear of injections, mostly due to injection-related pain. Pediatric studies with routine vaccines have shown topical anesthetic EMLA cream (lidocaine and prilocaine, Astra Pharmaceuticals, Inc.) and the topical vapocoolant Fluori-Methane (dichlorodifluoromethane and trichlorodifluoromethane, Gebauer Co.) to be equally effective in reducing pain from vaccinations. EMLA cream is expensive and requires a 60-min application, while Fluori-Methane (FM) is immediate in onset of action and inexpensive. Skin anesthesia begins at 10 degrees C. Fluori-Methane can briefly cool the skin to 0 degrees C.

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